Our Innovation Partners

NanoString
High Plex, Spatial Profiling of Proteins and RNA from FFPE

Combining standard immunofluorescence techniques with digital optical barcoding technology, the GeoMx^® Digital Spatial Profiler enables high plex, spatially-resolved profiling of protein and RNA. The GeoMx Assays allow for imaging and profiling from a single FFPE or fresh frozen tissue section.

• Quantify with spatial context 150+ proteins and up to the whole transcriptome
• Focus on rare cells or compartment-specific regions of interest in tissue
• Preserve precious samples with non-destructive processing

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ACD
A Fully Integrated RNA ISH Solution

Complete up to 30 slides in a single 11-hour run for single plex (and a 14-hour run for duplex) with high-throughput staining. This solution is:

• Highly specific – Amplifies signals using double z probe strategy and simultaneous background suppression strategy to ensure target-specific binding
• Sensitive & Quantitative – Detects single RNA molecules at single cell resolution
• Morphological – Provides cell specific expression in information intact tissue architecture
• Universal – Use for virtually any gene, species or tissue

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Ultivue
Single Step Multiplexing, Fully Automated

Create up to 30, five color multiplex slides in under 6 hours on BOND RX research stainer whilst preserving tissue morphology and integrity. Spend less time perfecting difficult manual techniques and more time focusing on your next research breakthrough.

• Survey and analyze cell phenotypes with spatial context within the tumor microenvironment though high performance tissue-based biomarker multiplex assays
• Multiplex on a single slide, using a single antibody cocktail and incubation step, powered by DNA barcoded antibodies with unique, complementary, fluorescent DNA barcodes
• Preserve sample integrity for additional analyses without damaging tissue or cross talk
• Image and analyze with Aperio VERSA and Aperio Cellular IF Algorithm

Navinci
Fully automated Navinci in situ proximity ligation assays: Naveni® kits for BOND RX/RX^m research stainer.

Navinci in situ proximity ligation assays offer novel technology with a choice of chromogenic and fluorescent readout on the BOND RX and BOND RX^m automated research staining platform by Leica Biosystems.

• Detect protein-protein interactions and post-translational modifications efficiently using the BOND RX research stainer, ensuring high precision and accuracy.
• Visualize specific protein targets like PD1/PD-L1 while preserving intact cell and tissue morphology, providing a holistic understanding of spatial protein relationships.
• Ready-to-use kits optimized for FFPE samples and reagents sufficient for 30 FFPE tissue slides.

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Cell Signaling Technology (CST)
SignalStar™ Multiplex IHC Fully Automated on the BOND RX and BOND RX^m Research Staining Platforms

Streamline multiplex spatial image generation and analysis with flexible, rigorously validated antibody panels and optimized protocols.

• Stain 10 8-plex samples in two days with validated protocols on the BOND RX research stainer.
• Remove up to 12 hours of hands-on time from the SignalStar workflow with automation.
• Build panels in four simple steps with an expanding menu of oligo-conjugated, IHC-validated primary antibodies.

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