Cell IDx

The new Leica Biosystems offering is optimal for research histopathology labs that seek to benefit from multiplexing immunohistochemistry (IHC) or IF for low-plex research applications. The Cell IDx portfolio by Leica Biosystems is a high throughput, low-plex solution that enables the custom detection of multiple primary antibodies from any species on the BOND RX. Unlike high-plex exploratory experiments, the unique Tag technology allows for targeted experiments to generate spatial information in days rather than weeks.

Fluorescent & Chromogenic Multiplex Immunohistochemistry (IHC) Staining Technology

UltraPlex fluorescent multiplex immunohistochemistry (IHC) and chromogenic multiplex immunohistochemistry comprise a paradigm-shifting technology that addresses the needs of precision medicine for multiplex IHC detection of proteins on tissues.

Cell IDx has developed a proprietary, Tag technology to address the need for unrestricted, simple, rapid, and simultaneous detection of multiple biomarkers in any immunoassay. The underpinnings of the technology comprise novel Tag design and their detection with high affinity anti-Tag antibodies. Initially, we have directed our UltraPlex technology to the development of fluorescent multiplex immunohistochemistry (IHC) and chromogenic multiplex immunohistochemistry (IHC) tissue-based assays. Methods for chromogenic and fluorescent detection of multiple markers have long been an unmet need. Our UltraPlex technology presents solutions to both assays overcoming many limitations.

Enable Translational and Preclinical Tissue Biomarker Profiling.

UltraPlex multiplex immunohistochemistry (IHC) is a simple, fast, and fully automated multiplex staining technology. UltraPlex reagents are offered kitted for optimal immunofluorescent or brightfield chromogenic staining. The UltraTag labeling solutions allow for custom conjugation of your selected antibody. Generate beautiful images and data on biomarker expression and spatial localization of key cell subtypes using BOND RX, RX^m staining system, Aperio VERSA, and Aperio GT 450 scanner.

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UltraPlex: Human Fluorescent Panels

Our state of the art UltraPlex fluorescent multiplex immunohistochemistry (IHC) tagging technology enables identification, quantitation and spatial biomarker profiling of immune subsets in human FFPE tissue sections – all in a few hours on a single slide.

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UltraPolymer™ HRP Detection

UltraPolymer anti-species-HRP secondary detection reagents are fully optimized on the BOND RX for immunohistochemistry (IHC), and combine high sensitivity with low background.

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Chromogens & IHC Reagents

Cell Palette Chromogens are highly sensitive chromogen substrates optimized for use in immunohistochemistry (IHC) staining with HRP- and AP- labeled detection reagents. A highly effective purple hematoxylin counterstain is also available.

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UltraPlex: Human Chromogenic Multiplex Panels

Our chromogenic multiplex immunohistochemistry (IHC) technology uses our proprietary UltraPlex tagging system to allow simultaneous staining using cocktails of antibodies. Combined with a single antigen retrieval step and using BOND RX / RX^m autostainers and Aperio brightfield scanners, this simple, rapid chromogenic multiplex staining allows out of the box access to brilliant chromogenic biomarker profiling of tissue sections.

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UltraTag Multiplex Labeling Kits

UltraTag labeling kits allow you to transform your great immunohistochemistry (IHC) antibodies into fluorescent or chromogenic multiplex IHC staining panels. Choose the number of kits you require (1 per antibody), and then rapidly transform your IHC antibodies into four-color fluorescent multiplex, or three-color chromogenic multiplex immunohistochemistry panels. UltraTag kits efficiently label 50ug @ 1.0mg/mL of high-affinity, purified antibody in ~ 2 hours.

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UltraPlex: Mouse Fluorescent and Chromogenic Multiplex

Our state-of-the-art UltraPlex fluorescent and chromogenic multiplex tagging technology enables identification, quantitation, and spatial biomarker profiling in mouse FFPE tissue sections - all in a few hours on a single slide.

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