Pre-Analytics-and-Histology-Research-Solutions

Pre-Analytics and Histology Research Solutions

Tissue-Based Research Workflows: Why Quality Matters

Quality, once lost, cannot be regained. Upstream pre-analytic quality is imperative to generating high-caliber data for exploring spatial biology, from IHC to multiplexing to plotting the tumor microenvironment.
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A good quality process lays the foundation for quality research results. Leica Biosystems recognizes the importance of focusing on “why quality matters” throughout the workflow cascade of tissue-based research and its impact on downstream results. Optimizing efficiencies can help build trustworthiness, improve quality, and impact downstream staining applications.

When designing a research project plan or building a new laboratory, one must learn how to assess each step of the pre-staining process with an eye to quality that can create repeatable and reliable results.

  • An essential step in good quality staining of a tissue specimen is through fixation and subsequent tissue processing.
  • Consistency in tissue section thickness, and the chemistry of tissue adherence to slides is crucial in producing the most intact and reliable morphological specimens that are required for high-quality staining.
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Tissue Processing

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Rapid Processing. Proven Quality.

Biopsies, resections, or fatty specimens; different tissues need different treatments. The scalable range of single or dual retort processors deliver optimized processing for each sample without slowing down your research laboratory.

In a research laboratory no two days are ever the same. Establish and adapt a workflow to meet the demands of your laboratory every day, with short cycle times and flexible processing protocols. In-built intelligent automation helps prevent user error to improve efficiency and maximize productivity.

Learn how to optimize your tissue processing workflow by:

  • Implementing best laboratory practices
  • Optimizing and enhancing histology workflow protocols and using quality reagents and consumables
  • Minimize the need for repeat downstream testing

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Here are some resources we’ve chosen for you:

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Lessons from the Laboratory: Optimizing Your Tissue Processing

In this webinar, Robin Fitzl, Senior Field Applications Specialist at Leica Biosystems, shares her insights and tips on proper tissue processing.

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Tissue Processing Artifacts: Checklist for Success

Learn more about tissue processing artifacts, what is "optimal" and what is "not," and how to optimize tissue processing techniques.

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Tissue Processing: A Cornerstone to Quality Downstream Testing

As immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurately interpreting disease processes.

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Cryosectioning

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Make Critical Discoveries Sooner with Leica Biosystems Cryosectioning Solutions

Research environments require flexibility and adaptability for sectioning diverse tissues and materials.

Cryo-sectioning is often the preferred methodology, providing superior antigenicity, and more accurate detection of antigens in downstream applications. Automation has changed the game in cryosectioning, offering reproducibility and high-quality sectioning over the manual method.

  • Benefit from reproducible results for molecular analysis
  • Quality and precision in sample preparation are crucial for intact RNA, DNA and protein retrieval
  • Prepare and preserve morphology, genetic material, and antigenicity with a simple and flexible solution

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Here are some resources we’ve chosen for you:

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Histology Hacks for Cryosectioning

Research environments require flexibility and adaptability for sectioning diverse tissues and materials. Cryosectioning is often the preferred methodology, providing superior antigenicity and more.

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Cryosectioning 101 for Research Q&A

Questions included in the document are advice on tissue tearing, keeping samples at a low temperature when working and preference for high, or low-profile blades.

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Tips for Choosing an Embedder

When choosing an embedder, three areas should be considered to maximize your purchase: Simple Operation, Smooth Workflow and Precise Control.

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Research Microtomy

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Preparing tissue specimens for histological examination requires care, skill and sound procedures. Broaden your research with a wide selection of blade and specimen holders enabling you to discover new breakthroughs in research for biomedical to industrial applications.

  • Benefit from customized settings for comfort and efficiency
  • Prepare high quality, non-human paraffin sections for all your research needs
  • Achieve faster trimming and consistent cuts

The new portfolio of Research Microtomes facilitates faster trimming with new coarse feed wheel options allowing you to customize the direction of rotation.

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Here are some resources we’ve chosen for you:

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Research Microtome Comparison Guide

What are the important features when choosing a microtome? Here is an easy-to-use microtome guide to help you through the process.

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4 Tips for Buying a Microtome

What should you look for when purchasing a microtome? Here, we offer 4 tips that will help you through the process.

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Research Microtome Buying Guide

Reliable and precise microtomes are designed to provide high-quality sections and enhanced efficiency.

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Selected Solutions for your Research Needs

Leica Biosystems can help you build quality into your research projects with integrated and optimized instruments and solutions. We want to be your end-to-end partner in building quality into and throughout your tissue-based research.

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For research use only. Not for use in diagnostic procedures.

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