Discover the Leica Biosystems Advantage
Leica Biosystems commits to partner with researchers like you to build rigor, embrace flexibility and optimize assays by connecting instruments, partner technologies, and applications support as the foundation of our work, inspiring credibility within your research program from bench to bedside and beyond.
Translational research projects are as novel as the technologies that drive them. We support scientists with solutions that bring automation, flexibility, and optimization to scale up your success and move quickly and efficiently into practical application.
Automation
Collecting rigorous technical and biological replicate data from instruments and protocols is central to developing accurate and reliable research results. For tissue-based research, there are opportunities to automate at every stage.
Flexibility
Open systems and solutions invite deep dives into cellular analysis with fully customizable protocols and integrated technologies that test the limits of your research.
Optimization
Our scientists, instruments, and applications specialists are your expert partners in building repeatability and precision into your research program’s assays, minimizing precious tissue utilization, and ensuring your instruments perform at their optimal capacity.
Subscribe today to learn about our upcoming symposiums and new research-focused product launches.
Research Highlights
Automated TRCBC1 and TRBC2 BaseScope™ as a Novel, Quicker and Cheaper Method for the Diagnosis of T-Cell Lymphoma
Learning Objective:
At present, cases of suspected T-cell lymphoma undergo T-cell receptor clonality studies, which introduce clinical delay, are costly and require highly trained staff for interpretation, as well as losing any morphological or immunophenotypic context of clonal populations of cells.
The University of Cambridge undertook a pilot study in T-cell lymphomas and corresponding benign samples on the BOND RX research stainer, using BaseScope™ probes located in the highly divergent 3’UTRs of TRBC1 and TRBC2.
Fluorescent Multiplex Staining of RNA and Protein Targets on the BOND RX Research Stainer
Learning Objective:
The Experimental Histopathology facility at the Francis Crick Institute has been using the BOND RX system since 2020 to optimize bespoke RNAscope assays, and multiplex immunofluorescence panels using OPAL fluorophores and multimodal RNA/protein staining in addition to running routine immunohistochemistry.
Characterizing the Tumor Microenvironment through Immunophenotyping and Spatial Biology using Ultivue 8-plex Immunofluorescence Technology on the BOND RX Research Stainer
Learning Objective:
Using custom-designed Ultivue 8-plex kits on the BOND RX system by Leica Biosystems, it enables the definition of the T-cell phenotypes spatially and quantitatively. This is especially important in treatment response monitoring and TME infiltration assessment in immunotherapy clinical programs at Adaptimmune where next generation SPEAR-T cell have been developed using Adaptimmune’s affinity-enhanced tumor antigen targeting TCR technology.
Help Turn Theories Into Action
The research partner that leverages beginning-to-end solutions that automate, standardize and optimize your translational research workflow
BOND RX - Fully Automated Research Stainer
Speed up your next big discovery. Use the BOND RX stainer to confidently complete IHC, ISH, FISH, CTC, multiplexing, and other tests. Explore your ideas in a variety of ways via reagents, detection, and customizable protocols. The BOND RX stainer provides an easy way for labs to fully automate tests and accelerate research programs.**
Aperio VERSA – brightfield, fluorescence, and FISH digital pathology scanner
Delivering excellence in IHC, ISH, and fluorescent tissue-based research including multiplex whole slide scanning.
The Aperio VERSA is ideal for scanning multiplex slides at any magnification from 5x to 63x for the whole slide without the need for spectral imaging.
For Research Use Only. Not for use in diagnostic procedures.
* Aperio is a trademark of the Leica Biosystems group of companies in the USA and optionally in other countries.
** BOND is a trademark of Leica Biosystems and its affiliates.