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Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.
| Publication Year: |
2022 |
| Country: |
USA |
| PMID: |
PMC9173818 |
| Publication: |
Proc Natl Acad Sci U S A. 2022;119(21):e2202012119. doi:10.1073/pnas.2202012119 |
| Institute: |
Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH , 43210;
Neuroscience graduate program, The Ohio State University, Columbus, OH , 43210;
Infectious Diseases Institute, The Ohio State University, Columbus, OH , 43210;
Faculty of Pharmacy, Helwan University, Cairo,11731 Egypt;
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH , 43210;
Department of Biomedical Informatics, The Ohio State University, Columbus, OH , 43210;
Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH , 43205;
Department of Pathology, The Ohio State University, Columbus, OH , 43210;
Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, NY , 10027;
Department of Microbiology and Immunology, Emory University, Atlanta, GA , 30322;
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA , 30322;
Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA , 30322;
Department of Neuroscience, Chronic Brain Injury Discovery Theme, The Ohio State University, Columbus, OH , 43210;
Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH , 43205;
Center for Informatics Science, Nile University, Giza, 12525, Egypt;
Department of Neurological Surgery, The Ohio State University, Columbus, OH , 43210 |
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Instrument:
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BOND RX |
| Authors: |
Eltobgy MM, Zani A, Kenney AD, et al. |
| Study Goals: |
To investigate the fundamental roles for the noncanonical inflammasome molecule Caspase-4/11 in promoting pathological inflammatory and prothrombotic pathways in severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) infections |
| Keywords: |
innate immunity, SARS–CoV-2, thrombosis |
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