Aperio GT 450 – Automated, High Capacity Digital Pathology Scanner with Enhanced Features

Leading Innovation with Proven Technology for the Research Laboratory

With over 25 years of Digital Pathology innovation, Leica Biosystems delivers performance and reliability.

Our renowned Aperio GT 450 scanner has 40+ patents designed to support flexible scanning requirements and automated workflows. With a 32 second scan speed* and output of 81 slides per hour at 40x*, scanning can be completed quickly with confidence.

Continuous innovation, delivering scalable features**, including Manual Scan capabilities, DICOM compatible files, Extended Focus, and Aperio iQC software, provide efficient workflows and excellent image quality, ensuring seamless integration and secure, optimized delivery of your research.

Manual Scan
Valuable for your workflow and essential for high-quality results – Take control of image quality with Manual Scan. Easily adjust scan settings and re-scan slides without removing them from the scanner, ensuring excellent image quality when automated scan results aren’t enough.

Extended Focus
Optimal image focus and quality that minimizes storage space – Capture images with extended focus and greater depth of field. This feature enhances the clarity of the entire tissue by combining areas of optimal focus across multiple layers into a single composite image, helping to save on file storage space.

Default Calibration Point
Capture true image quality with no effort required – Prevent image striping before it occurs with Default Calibration Point. This proactive, standard feature, now on the Aperio GT 450 scanner, replaces a problematic calibration point with a default clean one, ensuring high-quality images every time.

DICOM with 20x and 40x, and Z-Stack
High-quality images with consistent compatibility – Both the 20x and 40x magnification options provide clear and detailed views of samples, while the Z-Stack feature allows for multiple focused images to be combined. Together, these features ensure compatibility with DICOM standards for pathology, demonstrating our commitment to high-quality imaging.

Aperio iQC Software
Utilize AI to help detect image artifacts and save time – Aperio iQC software connects seamlessly with the Aperio GT 450 scanner, helping laboratory professionals detect digital and histological artifacts during the review of scanned whole slide images.

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For Research Use Only. Not for use in diagnostic procedures.
*Scan speed assumes 15mm x 15mm area at 40x
** Optional features available to meet your workflow requirements
Aperio is a trademark of the Leica Biosystems group of companies in the USA and optionally in other countries. GT and GT 450 are trademarks of Leica Biosystems Imaging, Inc. Other logos, product and/or company names might be trademarks of their respective owners.

PROVEN TECHNOLOGY FOR RESEARCHERS

Effortless scanning, exceptional results with excellent image quality, innovative technology and seamless integration – all driven towards faster turnaround time and accuracy for your important projects

MANUAL SCAN

Delivering researchers with an efficient solution for variability in slide preparation, Manual Scan provides:

Faster slide delivery with immediate rescanning from the same location.
Quick resolution of image issues by lab technicians including faintly stained IHC slides, small tissue fragments, low density tissues etc.
High-quality slides from challenging tissues.
Streamlined workflow and improved lab efficiency.

EXTENDED FOCUS

Experience an efficient imaging solution that improves image quality while reducing storage needs. Extended Focus features include:

Viewing all cells in focus on a single image, eliminating the need to scroll through layers.
Smaller file sizes than Z-Stack images speed up file transfers, improving collaborative activities.
Ideal in applications where thick specimens are viewed, which make the extended depth of field of images an issue to address.

DICOM with 20x,40x and Z-STACK

Aperio GT 450 uses a high-performance objective manufactured by Leica Microsystems, which has produced world-class optics since 1847. Leica optics deliver exceptional image quality

Available alongside .svs, DICOM enables image clarity, improved collaboration and a streamlined workflow.
20x and 40x options for clear and detailed views of samples
Z-Stacking enables the review of slide samples at varied heights

PROVEN TECHNOLOGY FOR LAB MANAGERS

Deliver rapid results with confidence.
The Aperio GT 450 is simple to operate and helps you complete scanning quickly and easily, so you can focus on other tasks in the lab: 15 racks of 30 slides (450 slides total) can be loaded directly from HistoCore SPECTRA CV Coverslipper into the Aperio GT 450. The slides are then automatically scanned at 81 slides per hour at 40x for a 15mm x 15mm area.

MANUAL SCAN

Providing lab technicians with an intuitive and efficient scanning solution, the benefits of Manual Scan include:

Easy-to-learn functionality that technicians can quickly navigate. Choose the scan area, set focus points and calibrate with ease.
Enhanced control and confidence throughout the scanning process.
Ability to successfully scan challenging slides with greater ease.
Improved workflow efficiency.

DEFAULT CALIBRATION POINT

The Aperio GT 450 Default Calibration Point reduces the chance of striping from the start, allowing lab managers to maintain image clarity and avoid corrective measures. This ensures consistently high-quality results with no extra effort.

APERIO iQC SOFTWARE

Optional Aperio iQC software enhances image quality control, ensuring confidence before scans are delivered to the researcher.

AI-enabled detection of whole slide image (WSI) artifacts, with notifications and a quality control dashboard to flag issues and recommend actions.
Algorithms designed to analyze WSIs and identify potential artifacts.
Automatic assessment to flag substandard slides, optimizing manual review and lab technicians’ time.

PROVEN TECHNOLOGY FOR IT PROFESSIONALS

The Aperio GT 450 offers fast, secure, and flexible IT architecture. A centralized Scanner Admin Manager (SAM) server and dedicated software provides you with a data management solution that can remotely set up and monitor multiple Aperio GT 450s at a time.*

Comprehensive cybersecurity including encryption and login controls
Centralized scanner management to set up and monitor multiple scanners
Two 10GB network connections on the SAM server
Scalable set up for hub and spoke configurations
HL7 compatible for easy integration into LIS , LIMS or PACS
Supports dedicated logins for each Aperio GT 450 scanner

SAM SERVER

No more workstations needed. A centralized Scanner Admin Manager (SAM) enables IT professionals to scale up Digital Pathology operations securely and efficiently. SAM server and software allow IT managers to set up and monitor Aperio GT 450 scanners via the network, including dashboard status views, PIN controls and log out times.

DICOM FILE

The DICOM format enhances compatibility for Z-Stacking, 20x and 40x magnification, offering high-quality images that can be easily shared and accessed across different systems. Now available alongside .svs, DICOM enables image clarity, improved collaboration and a streamlined workflow.

Image Quality Tested by Scientists for Scientists

(for best viewing results we recommend the Aperio Viewing Station which includes a calibrated monitor)

Precision, Potential to Scale, and Peace of Mind

Digital pathology scan speeds have not always been fast enough at 40x magnification to keep up with high-volume scanning (120k+ slides per year). Real-Time Focusing (RTF)** offers a potential solution to this problem. It’s a novel method to capture a digital image that combines an imaging line sensor and a focusing line sensor.

While scanning, the focusing line sensor receives focusing data of the tissue.
Proprietary algorithms determine the best focus value.
Then, each best focus value is treated like a control loop with the mechanics, feeding the best focus value to the objective height on the fly.
The positioning adjustments of the objective are performed continuously (in real time) in order to enable the imaging line sensor to capture the image at its best possible focus. Hence, real time focusing.

**US Patent no. 9,841,590

Excellent Image Quality with Custom-Made Leica Objective

The high-performance objective included with the Aperio GT 450 is specifically designed to maximize field of view for high speed digital pathology scanning. Most objective are designed similar to the human eye: round, which focuses light in the center and limits field of view. The objective on the Aperio GT 450 includes an extra-wide flat field correction that enables a much larger field of view (1mm) that can accommodate extremely large digital images for fast scans and 0.26 um/pixel resolution at 40x magnification*.

*Available in 20x magnification.

Product Specifications

APERIO GT 450 SUMMARY OF SPECIFICATIONS

Maximum Slide Capacity:	450
Rack capacity:	15 racks of 30 slides, 15 racks of 20 slides
Racks compatible with Leica HistoCore SPECTRA Workstation:	Yes
Continuous rack loading while scanning:	Yes
Priority rack scanning:	Yes
Manual Scan:	Yes
DICOM compatible with 20x, 40x and Z-Stack:	Yes
Extended Focus:	Yes
Aperio iQC software:	Yes
Default Calibration Point:	Yes
Automated Narrow Stripe:	Yes

Z-Stacking:	Yes
Magnification:	20x, and 40x
Resolution:	0.26 μm/pixel at 40x
Scan speed (15mm x 15mm area at 40x):	32 sec
Sustained throughput (15mm x 15mm area at 40x):	81 slides/hr
Automated Image Quality Check:	Yes
Slide sizes accepted:	1x3
Field of View (FOV)	1mm
Barcode engines:	1D and 2D symbology
Dimension:	20.8” (52.83 cm) W x 28” (71.12 cm) L x 19.5” (49.53 cm) H
Weight:	140 lbs (63.5 kg)

Resources

Introducing the Aperio GT 450

Aperio GT 450 Scanner - Manual Scan

Download

Broschüren

Brochure - Aperio GT 450 with Enhanced Features - 230234 Rev E Size: 8.02 MB, Typ: pdf